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Spitz is a member of the EGF receptor family and was originally identified as a potent oncogene in different tumor types, including epidermal carcinomas. All Spitz proteins share extensive sequence homology, including a unique C-terminal amino acid motif. Homology models of Spitz proteins based on c-erbB-2, ErbB2, and ErbB3 were constructed and C-terminal orientation of Spitz was analyzed. The models suggest that Spitz residues 501-524 form a surface extension of the extracellular ligand binding domain and in addition, conserved residues 551-556 and 577-585 define a second ligand binding motif. Within the two motifs a highly conserved stretch of amino acids occurs. Molecular dynamics simulations of Spitz and its fragments showed a distinct conformational behavior for the C-terminal part of Spitz, suggesting a contribution of the C-terminal part to the conformational flexibility of Spitz and its function in EGFR signaling.Police in the US have released the 911 call after a Texas police officer used an AR-15 to end a car chase involving a suspect who had allegedly been shooting at police.

According to the Austin American-Statesman, the incident began when a police officer in Round Rock, a suburb of Austin, spotted a pickup truck that matched the description of one seen fleeing the scene of a crime.

After ordering the driver to stop, shots were fired.

Police later discovered nine victims and an officer was shot in the hand, authorities said.

The suspect, who has not been identified, was charged with aggravated assault with a firearm.

“If we had not stopped the vehicle, the (Round Rock) police department would have potentially been shot by the person they were pursuing,” said Department of Public Safety Sgt Alicia Pierce.

She added: “We are grateful that no one was killed. We are working on releasing the 911 call of the officer that shot back and it is very disturbing.”

There is currently an ongoing investigation into the officer’s

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